Journal article
Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis
T Sampaio Rodrigues, LJ Garcia Quarto, SC Nogueira, JD Theuerle, O Farouque, LM Burrell, AN Koshy
American Heart Journal | MOSBY-ELSEVIER | Published : 2024
Abstract
Early decongestion therapy with intravenous diuretics may be associated with improved outcomes in acute heart failure (AHF), however data is conflicting. This meta-analysis sought to evaluate the impact of door-to-IV diuretic (D2D) time on mortality in patients with AHF. Pooled estimates from observational studies comprising 28,124 patients, early IV diuresis (reference time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in AHF (OR 0.77; 95% CI 0.64-0.93), despite no significant in-hospital death reduction (OR 0.84; 95% CI 0.57-1.24).
Related Projects (2)
Grants
Awarded by National Heart Foundation of Australia
Funding Acknowledgements
A.N.K. is a recipient of the National Health and Medical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship, Royal Australasian College of Physicians Blackburn Scholarship (1150874) and the Heart Foundation Post-Doctoral Fellowship (105969) . All other authors have no relevant financial support or industry affiliations to declare.